Estradiol-Indole Hybrids: SERT and ERβ Inhibition Data for 18 Compounds

Chunyu Wu published data on 18 novel estradiol-indole hybrid compounds designed as potential antidepressants. The dataset includes in vitro and in vivo results, such as IC50 and EC50 values for serotonin transporter inhibition and estrogen receptor β agonism, as well as behavioral test outcomes from mouse models. It was last updated on 2026-05-19.

Use Cases

• Modeling structure-activity relationships based on synthesized compound properties.
• Analyzing dual-target efficacy based on SERT inhibition and ERβ agonism data.
• Correlating in vitro binding affinity (IC50/EC50) with in vivo behavioral outcomes from forced swim and tail suspension tests.
• Screening for drug candidates with favorable oral absorption and brain penetration profiles.

Strengths

• Includes specific potency metrics for a lead compound (I11), such as an IC50 of 16.92 ± 1.71 nM for SERT inhibition.
• Reports in vivo validation from two established mouse stress models (CUMS and CSDS).
• Data is associated with a clear, peer-reviewed research objective described in the metadata.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 2.3 KB, indicating limited scope.

Provenance

Source

Chunyu Wu via figshare

Collection Method

Experimental synthesis and pharmacological testing described in the research.

Freshness

Last updated 2026-05-19 17:38:56; freshness should be verified.