Development of Novel Estradiol-Indole Hybrids Targeting SERT and ERβ as Potential Antidepr

18 novel estradiol-indole hybrid compounds were synthesized and evaluated for dual-target antidepressant activity. The dataset includes IC50 and EC50 values for serotonin transporter inhibition and estrogen receptor β agonism, with in vivo results from mouse models of chronic stress. Author Chunyu Wu published the data on figshare in May 2026.

Use Cases

• Predicting compound activity based on structural features and measured IC50/EC50 values.
• Modeling structure-activity relationships for SERT inhibitors and ERβ agonists.
• Screening for novel dual-target drug candidates based on the described hybrid scaffold.

Strengths

• Includes specific potency metrics for 18 synthesized compounds, such as an IC50 of 16.92 ± 1.71 nM for SERT inhibition.
• Contains in vivo validation data from two established mouse behavioral models (CUMS and CSDS).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental synthesis and pharmacological testing described in the associated research.

Freshness

Last updated 2026-05-19 17:38:58; freshness should be verified.