Glucocorticoid Receptor Antagonist Compounds with In Vivo Activity

Medicinal chemistry data details the discovery and optimization of a series of selective piperazine-based glucocorticoid receptor antagonists. The dataset describes compounds derived from a simplified scaffold, with three key molecules progressed to in vivo proof-of-concept studies. It was authored by Lorna A. Duffy and shared via figshare in April 2026.

Use Cases

• Analyze structure-activity relationships for piperazine-based compounds to identify key molecular features.
• Compare simplified scaffold compounds against the reference molecule relacorilant (CORT125134).
• Screen for candidate molecules with the desired antagonist profile for further in vivo testing.

Strengths

• Data is recent, last updated in April 2026.
• Includes results from in vivo proof-of-concept studies for three key compounds.

Limitations

• The dataset is very small at 8.9 KB, indicating limited scope and likely few data points.
• Specific structural data columns, row counts, and experimental metrics are not provided.

Provenance

Source

figshare, authored by Lorna A. Duffy.

Collection Method

Reported discovery and optimization from medicinal chemistry research.

Time Range

null

Freshness

2026-04-07

Geography

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