TSSK1 and TSSK2 Degrader Profiles for Sperm Function Disruption

4.6 KB of data from a study reporting the design and characterization of targeted degraders for testis-specific kinases TSSK1 and TSSK2. The dataset includes quantitative cellular profiling results, such as a DC50 of 10 nM for compound 5.1, and ex vivo sperm function assays showing up to an 80% reduction in TSSK2 and a 97% reduction in motility. The data was authored by Jerrett A. Holdaway and last updated on 2026-06-02.

Use Cases

• Training models to predict degrader potency based on quantitative cellular profiling data like DC50 and Dmax.
• Analyzing the relationship between kinase isoform reduction and functional sperm loss based on reported motility and in vitro fertilization metrics.
• Optimizing degrader compounds by studying metabolic N-dealkylation and efflux characteristics mentioned in the description.

Strengths

• Includes specific quantitative metrics such as a DC50 of 10 nM and a Dmax of 68% for a key degrader compound.
• Reports functional outcomes with concrete numbers, including an 80% reduction in TSSK2 and a 97% reduction in sperm motility.
• Data is associated with a proof-of-concept study for a novel application of targeted degradation in sperm cells.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 4.6 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from the design, synthesis, and characterization of targeted degraders, including cellular profiling and ex vivo sperm assays.

Freshness

Last updated 2026-06-02 19:04:04; freshness should be verified.