Development of Water-Trapping Pyrrole-2-carboxylic Acids as Broad-Spectrum Metallo-β-lacta

The dataset likely contains results from the structure-guided development of pyrrole-2-carboxylic acid derivatives as inhibitors of metallo-β-lactamases (MBLs). It was authored by Monisha Singha and last updated on May 14, 2026. The data supports the enhancement of carbapenem antibiotics against MBL-producing Gram-negative clinical isolates.

Use Cases

• Modeling inhibitor-enzyme binding based on crystallographic studies of Zn(II)-coordination.
• Evaluating compound potency against specific MBL variants (NDM-1, VIM-1, VIM-2, IMP-1) mentioned in the description.
• Assessing the enhancement of carbapenem activity against clinical isolates as described.
• Comparing the selectivity of water-trapping inhibitors versus metal-chelation based approaches.

Strengths

• Data is associated with peer-reviewed research involving crystallographic studies.
• The dataset is focused on a specific, clinically relevant target (B1 MBLs).
• The file size is 2.3 KB, indicating a compact and potentially focused dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Structure-guided development and crystallographic studies, as described.

Freshness

Last updated 2026-05-14 21:31:54; freshness should be verified.