Pyrrole-2-Carboxylic Acid Derivatives as Metallo-β-Lactamase Inhibitors

Monisha Singha published data on May 14, 2026, detailing the development of pyrrole-2-carboxylic acid derivatives as inhibitors for metallo-β-lactamase enzymes. The dataset likely contains results from structure-guided development and crystallographic studies targeting B1 MBLs like NDM-1, VIM-1, VIM-2, and IMP-1. It is a small dataset of 2.4 KB, stored in CSV format.

Use Cases

• Evaluating inhibitor potency against specific MBL variants (NDM-1, VIM-1, VIM-2, IMP-1) based on the description of targeted enzymes.
• Analyzing structure-activity relationships of pyrrole-2-carboxylic acid derivatives based on the described structure-guided development approach.
• Assessing the enhancement of carbapenem activity against MBL-producing clinical isolates based on the described biological results.
• Studying Zn(II)-coordination binding mechanisms in enzyme inhibition based on the crystallographic findings mentioned.

Strengths

• Dataset is openly licensed under CC-BY-NC-4.0 for non-commercial use.
• Crystallographic studies provide a structural basis for the inhibition mechanism, as described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 2.4 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Structure-guided development and crystallographic studies, as described.

Freshness

Last updated 2026-05-14 21:31:53; freshness should be verified.