DHODH Inhibitors Based on Vidofludimus Scaffold with Carboxylic Acid Bioisosteres

A medicinal chemistry dataset from figshare, authored by Alexandra Herrmann and last updated in June 2026, describes optimized dihydroorotate dehydrogenase (DHODH) inhibitors derived from vidofludimus. The 6.0 KB dataset likely contains compound structures and activity data, showing single-digit nanomolar potency against a range of viruses including SARS-CoV-2 with selectivity indices exceeding 50,000.

Use Cases

• Training predictive models for antiviral activity based on compound structural features.
• Screening for promising broad-spectrum antiviral candidates based on DHODH inhibition data.
• Analyzing structure-activity relationships for carboxylic acid bioisosteres in the vidofludimus scaffold.

Strengths

• Dataset is small (6.0 KB), facilitating quick download and initial inspection.
• Compounds described show high selectivity indices, exceeding 50,000, indicating strong therapeutic potential.
• Activity data covers a broad spectrum of viruses, including enveloped and nonenveloped DNA and RNA viruses.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains results from medicinal chemistry optimization experiments.

Freshness

Last updated 2026-06-03 11:36:30; freshness should be verified.