Inhaled Carfentanil Distribution and Cardiorespiratory Toxicity in Rats

Xiuping Gao published data on the tissue distribution of inhaled carfentanil and its cardiorespiratory effects in rats. The dataset, last updated on 2026-05-11, quantifies drug concentrations in peripheral and central tissues over time and records physiological responses. It includes results from experiments with different naloxone administration routes to determine the role of central versus peripheral opioid receptors.

Use Cases

• Modeling drug distribution kinetics based on quantified tissue concentrations over time.
• Analyzing the relative contribution of central vs. peripheral opioid receptors to cardiorespiratory failure based on naloxone administration routes.
• Correlating estimated deposited drug dose with recorded cardiorespiratory responses.

Strengths

• Data is derived from a controlled experimental design with specific exposure parameters (10.0 mg/m³ for 15 min).
• Includes quantified drug contents across multiple tissue types and time points.
• Compares cardiorespiratory responses under four distinct pharmacological intervention conditions.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a single rodent model study, limiting generalizability.

Provenance

Source

Xiuping Gao via figshare

Collection Method

Experimental data from rats exposed to aerosolized carfentanil in a plethysmograph.

Freshness

Last updated 2026-05-11 18:58:16; freshness should be verified.