Difluorocarbene-Enabled Amine Synthesis with 104 Reaction Examples

104 examples of primary, secondary, and tertiary amine synthesis via a metal-free method for selective Csp3–N bond cleavage and reconstruction. The dataset, authored by Huan Yuan, was last updated on 2026-06-02 and describes reactions featuring difluoromethylammonium ylide intermediates. The method is noted for mild conditions, good functional group tolerance, and suitability for late-stage pharmaceutical modification.

Use Cases

• Train reaction prediction models based on the described difluorocarbene-enabled C–N bond transformation.
• Benchmark synthetic feasibility or condition optimization algorithms based on the 104 documented examples.
• Study patterns in functional group tolerance for amination reactions as described in the methodology.

Strengths

• Includes 104 specific reaction examples.
• Method details include concrete features like metal-free conditions and good functional group tolerance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Huan Yuan via figshare

Collection Method

Likely contains experimental data from the described chemical synthesis study.

Freshness

Last updated 2026-06-02 12:26:59.