Birthweight Genetic Effects on Child DNA Methylation at Birth

829 birthweight-related DNA methylation sites from 2116 families in the Generation R Study. The dataset, published by Nicole Creasey in 2026, provides evidence for maternal genetic effects on offspring epigenetic patterns at birth. It includes polygenic scores for maternal and fetal birthweight predisposition and tests for mediation by 13 pregnancy health factors.

Use Cases

• Test for direct and indirect genetic effects on DNA methylation based on maternal and fetal polygenic scores.
• Analyze mediation of genetic effects by pregnancy health factors like gestational age.
• Investigate associations between aggregated methylation profile scores and birthweight predisposition.
• Replicate findings on the association between maternal genotype and offspring epigenetic patterns.

Strengths

• Focuses on 829 specific DNA methylation sites related to birthweight.
• Analyzes data from 2116 families, providing a substantial sample for genetic studies.
• Explicitly tests 13 pregnancy health factors as potential mediators.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Paternal genotype analysis was limited by lower sample size and lack of a dedicated GWAS.

Provenance

Source

figshare, author Nicole Creasey.

Collection Method

Data from the Generation R Study, with polygenic scores constructed from an existing 'pre-adjusted' GWAS.

Time Range

Temporal coverage is not specified in the description.

Freshness

Last updated 2026-04-14 14:40:03; freshness should be verified.

Geography

Spatial coverage is not specified in the description.