Lupus Clinical Trial Data with Cytokine-eQTL Interactions from 379 Samples

Gene expression and cis-eQTL summary statistics from a clinical trial for anti-IL-6 therapy in systemic lupus erythematosus patients. The data includes interferon status, drug exposure, and genome-wide expression measured at three time points across 379 samples from 157 individuals. It was produced by Emma E. Davenport using a random intercept linear mixed model with principal components as covariates.

Use Cases

• Identify cis-eQTLs based on summary statistics for gene-SNP pairs within 250kb of transcription start/end sites.
• Analyze longitudinal changes in gene expression based on interferon status and anti-IL-6 drug exposure measured at three time points.
• Investigate genotype-by-environment interactions using cytokine exposure and genetic variation data.
• Validate statistical models for eQTL mapping that incorporate random effects for subject and principal component covariates.

Strengths

• Includes longitudinal measurements from three distinct time points per individual.
• Data is derived from a controlled clinical trial setting with 379 samples from 157 patients.
• Analysis employed a random intercept linear mixed model, a robust method for repeated measures.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the expression and summary statistics files is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Emma E. Davenport

Collection Method

Measured in a clinical trial for anti-IL-6 in patients with systemic lupus erythematosus.