BI01383298: Potent and Selective Inhibitor of the Hepatic Citrate Transporter NaCT

Andrew Quigley published a dataset on figshare in April 2026 describing the discovery of a nonacidic small-molecule inhibitor of the sodium-coupled dicarboxylate transporter NaCT (SLC13A5). The dataset, stored in a 1.1 KB CSV file, includes details on the chemical probe BI01383298, its inactive analog BI01372674, and an alternative probe BI01455810. These compounds are presented as tools for studying the physiological and pathological roles of NaCT in metabolism and disease.

Use Cases

• Analyzing the potency and selectivity of chemical probes based on the reported IC50 and selectivity values.
• Studying the role of the hepatic citrate transporter NaCT in metabolic pathways based on the biological context described.
• Comparing active and inactive chemical analogs for structure-activity relationship studies based on the provided probe and analog.
• Investigating potential therapeutic targets for metabolic disorders based on the description of NaCT as a target.

Strengths

• Includes a highly potent chemical probe with a reported IC50 of 25 nM.
• Describes exceptional selectivity (>1000-fold) over other SLC13 family transporters.
• Provides an inactive analog for controlled experimental comparison.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (1.1 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from biochemical assays.

Time Range

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Freshness

Last updated 2026-04-28 23:45:03; freshness should be verified.

Geography

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