Lysine Fumarylation Sites and Enzymatic Pathways in Escherichia coli

857 endogenous lysine fumarylation sites identified in Escherichia coli using open-search mass spectrometry and enrichment techniques. The dataset likely contains results from integrated transcriptomic and proteomic analyses, mapping modifications linked to fumarate metabolism. Author Chen Chen published the data on figshare in April 2026.

Use Cases

• Identifying lysine fumarylation sites based on mass spectrometry data
• Analyzing enzymatic pathways for fumaryl-CoA synthesis and transfer based on described SucC–SucD and SpeG activities
• Investigating regulatory functions of fumarate in stress response pathways based on integrated transcriptomic and proteomic analyses

Strengths

• 857 endogenous lysine fumarylation sites mapped
• Data includes confirmation via chromatographic retention and MS/MS fragmentation comparisons with synthetic peptides
• Enzymatic pathway for regulation (SucC–SucD, SpeG, CobB) is elucidated

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Open-search mass spectrometry, antibody enrichment, metabolic tracing with deuterated fumarate

Freshness

Last updated 2026-04-10 06:05:26