NP12 PROTAC Degrader Efficacy Data for SAMHD1 in Pulmonary Fibrosis

Experimental data details the discovery and evaluation of NP12, the first intracellularly active SAMHD1 degrader. The dataset includes key metrics such as a DC50 value of 1.2 μM and a Dmax degradation efficiency of 89%. It was authored by Xing Chen and shared on figshare in April 2026.

Use Cases

• Model the relationship between NP12 concentration (e.g., 5 μM) and SAMHD1 degradation efficiency (Dmax of 89%).
• Analyze the DC50 value (1.2 μM) and time-to-degradation (48 h) for benchmarking against other degraders.
• Correlate in vitro degradation metrics with in vivo outcomes like fibrosis progression delay in the mouse model.

Strengths

• Reports specific, quantitative efficacy metrics like a DC50 of 1.2 μM and Dmax of 89%.
• Includes validation data from an in vivo bleomycin-induced pulmonary fibrosis mouse model.

Limitations

• The dataset is extremely small at 2.1 KB, indicating very limited scope and likely few data points.
• Data is derived from a single study focusing on one compound (NP12), limiting generalizability.

Provenance

Source

figshare, authored by Xing Chen.

Collection Method

Experimental results from laboratory research on a PROTAC degrader compound.

Freshness

Last updated in April 2026.