IRBM-Z-2: In Vivo Efficacy Data for a Zika Virus Protease Inhibitor

Esther Torrente published data on IRBM-Z-2, an optimized Zika virus NS2B-NS3 protease inhibitor, on figshare in 2026. The dataset likely contains results from biochemical, cellular, and mouse model studies. It is a small dataset of 5.1 KB, shared under a CC-BY-NC-4.0 license.

Use Cases

• Analyzing structure-activity relationships based on the series of N-carbamoylsydnone imine derivatives
• Modeling pharmacokinetic properties based on oral bioavailability and clearance data
• Evaluating antiviral efficacy in cellular assays based on potency against ZIKV NS2B-NS3 protease
• Assessing therapeutic potential based on prophylactic efficacy in mouse models of ZIKV infection

Strengths

• Data is associated with a compound showing nanomolar inhibitory activity
• Results include favorable oral bioavailability and low clearance metrics
• Dataset is openly shared under a CC-BY-NC-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 5.1 KB file size indicates a very limited scope of data

Provenance

Source

figshare

Collection Method

Likely contains experimental results from phenotypic antiviral screening and compound optimization.

Freshness

Last updated 2026-05-29 18:33:30; freshness should be verified