IRBM-Z-2: Data on a Zika Virus Protease Inhibitor Candidate

IRBM-Z-2 is a nanomolar inhibitor of the Zika virus NS2B-NS3 protease, as described in a research article by Esther Torrente. The dataset, shared on figshare in May 2026, is a 14.9 KB XLSX file containing supporting data for the compound's discovery and optimization.

Use Cases

• Analyzing structure-activity relationships for N-carbamoylsydnone imine derivatives based on the series mentioned.
• Evaluating pharmacokinetic properties like oral bioavailability and clearance based on the described favorable profile.
• Assessing in vivo prophylactic efficacy in mouse models of ZIKV infection as reported in the description.

Strengths

• Data supports a compound with nanomolar potency in biochemical and cellular assays, as stated.
• The dataset is associated with a compound demonstrating strong prophylactic efficacy in a mouse model, as reported.
• The file is provided in the widely compatible XLSX format.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's 14.9 KB size suggests a limited scope, likely containing summary or key results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Likely contains experimental data generated during the compound optimization process described.

Freshness

Last updated 2026-05-29 18:33:31; freshness should be verified.