Discovery of 1,2-Diol TRPV4 Antagonists with Efficacy in Organoid and Murine Models

Na Chen published a dataset on figshare in 2026 describing a series of optimized TRPV4 antagonist compounds. The data likely contains results from a single-point TRPV4 Ca2+ influx assay and phenotypic validation in 3D myocardial organoids and a murine TAC pressure-overload model. The dataset is 1.1 KB in size and is available in CSV format.

Use Cases

• Structure-activity relationship (SAR) analysis based on the series of active analogues
• Screening candidate compounds based on the TRPV4 Ca2+ influx assay results
• Validating anti-fibrotic efficacy based on the 3D myocardial organoid model
• Assessing in vivo cardiac function improvement based on the murine TAC pressure-overload model

Strengths

• Includes in vivo validation data from a murine transverse aortic constriction (TAC) model
• Reports a phenotypic IC50 of 6.45 μM for compound 26 in the organoid model
• Data is published under the CC-BY-NC-4.0 license, allowing for non-commercial reuse

Limitations

• The dataset is very small at 1.1 KB, indicating limited scope
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Likely contains experimental results from structure-guided optimization, a Ca2+ influx assay, and organoid and murine model validation.

Freshness

Last updated 2026-05-14 15:06:58