Discovery of a Biased Keap1-p62 PPI Inhibitor for p62 Aberrant HCC

A dataset describing the discovery and characterization of compound 13, a biased inhibitor of the Keap1-phosphorylated p62 protein-protein interaction. The data includes results from fluorescence polarization assays showing an IC50 of 0.11 μM and high selectivity over Keap1-Nrf2 inhibition. The dataset was authored by Ziquan Zhao and uploaded to figshare on 2026-05-30.

Use Cases

• Evaluating Keap1-p-p62 inhibitory activity based on fluorescence polarization assay results
• Assessing selectivity of Nrf2 pathway inhibitors based on the described bias for Keap1-p-p62 over Keap1-Nrf2
• Investigating ferroptosis sensitization in p62 aberrant HCC cells based on the described cotreatment with sorafenib

Strengths

• Includes a specific IC50 value of 0.11 μM for Keap1-p-p62 inhibition
• Describes a specific tumor growth inhibition (TGI) result of 95.3% from a combination treatment

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Likely contains experimental results from biochemical assays and cell-based studies.

Freshness

Last updated 2026-05-30 13:35:48; freshness should be verified