MS108 ENL Degrader: Potency and Selectivity Data for Acute Myeloid Leukemia Research

20.4 KB of CSV data from a structure-activity relationship study that discovered MS108, a highly potent ENL degrader. The dataset, authored by Kaixiu Luo and last updated in April 2026, reports a degradation potency (DC50) of 0.6 nM and an antiproliferation potency (GI50) of 1.19 nM in MV4;11 cells. It provides a chemical tool for the research community and a lead for therapeutic development against acute myeloid leukemia.

Use Cases

• Benchmarking new ENL degraders based on reported DC50 and GI50 potency metrics.
• Modeling structure-activity relationships for PROTAC molecules based on the described SAR study.
• Studying VHL E3 ligase recruitment and ubiquitin-proteasome system dependency in targeted protein degradation.
• Comparing pharmacokinetic properties of lead compounds for further therapeutic development.

Strengths

• Reports specific, high-potency metrics: DC50 of 0.6 nM and GI50 of 1.19 nM.
• Describes a compound with demonstrated selectivity and dependency on specific biological mechanisms (VHL, UPS).
• Dataset is shared under a clear CC-BY-NC-4.0 license for non-commercial research use.

Limitations

• The dataset is very small at 20.4 KB, suggesting limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from a comprehensive structure-activity relationship study.

Freshness

Last updated 2026-04-23 23:13:27; freshness should be verified.