46 Novel Thienopyrimidine Derivatives for Dual URAT1/GLUT9 Inhibition

46 novel polycyclic pyrimidine derivatives were synthesized via scaffold hopping and structure-guided design. Compound 17 showed potent dual inhibition of URAT1 (IC50 = 4.01 μM) and GLUT9 (IC50 = 1.60 μM). The dataset, authored by Qian Yang and updated in May 2026, likely contains molecular structures and experimental results.

Use Cases

• Evaluating dual-target inhibition efficacy based on URAT1 and GLUT9 IC50 values
• Comparing pharmacokinetic profiles based on bioavailability (F) data
• Assessing safety profiles based on acute toxicity test results
• Analyzing structure-activity relationships for polycyclic pyrimidine derivatives

Strengths

• Includes 46 novel compounds with experimental data
• Provides specific IC50 values (4.01 μM and 1.60 μM) for key targets
• Contains in vivo efficacy data showing a 82.4% reduction in serum uric acid

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect experimental bias inherent to the specific research project

Provenance

Source

figshare

Collection Method

Scaffold hopping and structure-guided design from lead compound F-5

Freshness

Last updated 2026-05-06 16:08:10; freshness should be verified