M9101: Aurora A PROTAC Degrader Potency and Selectivity Data

A dataset from 2026 by Yulin Mao, shared on figshare, describing the discovery of M9101, a potent and selective Aurora A PROTAC degrader. The 3.3 MB XLSX file likely contains experimental results, including a DC50 value of 2.3 nM in MD-MBA-231 cells and selectivity data from global proteomic analysis.

Use Cases

• Analyzing structure-activity relationships based on the promiscuous kinase inhibitor warhead transformation described.
• Evaluating degrader selectivity profiles based on the global proteomic analysis mentioned in the description.
• Comparing in vitro potency metrics like DC50 values based on the reported 2.3 nM result in MD-MBA-231 cells.
• Studying the feasibility of developing selective degraders from non-selective ligands as highlighted in the case study.

Strengths

• Includes a specific, potent DC50 value of 2.3 nM for Aurora A degradation in a cell line.
• Data is derived from a global proteomic analysis, suggesting a broad selectivity profile.
• Dataset is shared under a clear CC-BY-NC-4.0 license, defining reuse terms.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The dataset is small (3.3 MB), potentially limiting the depth or variety of data points.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from chemical synthesis, cell-based assays, and proteomic analysis.

Freshness

Last updated 2026-05-29 21:30:06; freshness should be verified.