M9101: Aurora A PROTAC Degrader Potency and Selectivity Data

A chemical biology dataset from figshare details the discovery of M9101, a potent and selective Aurora A PROTAC degrader. The dataset, authored by Yulin Mao and last updated in May 2026, includes potency measurements such as a DC50 of 2.3 nM in MD-MBA-231 cells and selectivity data from global proteomic analysis.

Use Cases

• Evaluating PROTAC degrader potency based on reported DC50 values.
• Assessing kinase degrader selectivity using global proteomic analysis results.
• Studying structure-activity relationships for degraders derived from promiscuous kinase inhibitors.

Strengths

• Includes a specific potency metric (DC50 of 2.3 nM).
• Reports selectivity data from a global proteomic analysis.
• Contains in vivo activity data for the degrader.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (357.7 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from chemical synthesis, cell-based assays, and proteomic analysis.

Freshness

Last updated 2026-05-29 21:30:04; freshness should be verified.