M9101: Aurora A PROTAC Degrader Potency and Selectivity Data

2.2 KB of data on the PROTAC degrader M9101, including its DC50 value of 2.3 nM in MD-MBA-231 cells. The dataset, authored by Yulin Mao and last updated in May 2026, originates from a study demonstrating the development of a selective kinase degrader from a promiscuous inhibitor. It highlights a chemical tool for probing noncatalytic kinase biology.

Use Cases

• Evaluating PROTAC degrader potency based on reported DC50 values
• Assessing kinase inhibitor selectivity based on global proteomic analysis results
• Studying the translation of promiscuous binders into selective degraders as described in the research

Strengths

• Includes a specific DC50 potency value of 2.3 nM
• Data is associated with a published study demonstrating in vivo activity
• Released under a clear CC-BY-NC-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The 2.2 KB size indicates a very limited data scope

Provenance

Source

Yulin Mao

Collection Method

Likely contains experimental results from a pharmacology study.

Freshness

Last updated 2026-05-29 21:30:02; freshness should be verified