M9101: Aurora A PROTAC Degrader Bioactivity and Selectivity Data

M9101 is a potent Aurora A PROTAC degrader with a DC50 value of 2.3 nM in MD-MBA-231 cells. The dataset, shared by Yulin Mao on figshare in May 2026, presents results from a global proteomic analysis demonstrating the compound's exceptional selectivity and in vivo activity. It provides a chemical tool for probing the noncatalytic biology of the kinase.

Use Cases

• Benchmarking PROTAC degrader potency based on the reported DC50 value of 2.3 nM.
• Analyzing kinase inhibitor selectivity profiles based on the global proteomic analysis mentioned.
• Studying structure-activity relationships for Aurora A degraders derived from promiscuous warheads.
• Validating in vivo target depletion models for PROTAC molecules.

Strengths

• Includes a specific, potent DC50 value of 2.3 nM for Aurora A degradation.
• Reports results from a global proteomic analysis, suggesting a selectivity assessment.
• Demonstrates in vivo activity, indicating translational relevance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 354.5 KB size suggests a very limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from chemical synthesis, cell-based assays, and proteomic analysis.

Freshness

Last updated 2026-05-29 21:30:05; freshness should be verified.