Aspergillus Fungal Metabolites with Anti-biofilm Activity and Biosynthetic Enzyme Data

Seven aromatic meroterpenoids, including two new compounds, were discovered from a newly identified Aspergillus fungus. The dataset, published by Pantao Chu in April 2026, includes bioactivity results showing compounds 2–7 exhibited significant biofilm eradication effects, with compound 5 inhibiting biofilm formation by 60.4%. Genome sequencing identified two functional prenyltransferases, AtUbiA3 and Pan9, providing biochemical insights into the biosynthesis pathway.

Use Cases

• Training models to predict anti-biofilm activity based on meroterpenoid structural features.
• Analyzing genome sequence data to identify biosynthetic gene clusters for prenyltransferases.
• Studying structure-activity relationships for novel fungal metabolites mentioned in the description.
• Investigating synergistic antimicrobial effects when compounds are combined with antibiotics like kanamycin.

Strengths

• Includes data on seven specific meroterpenoid compounds, with two being newly discovered.
• Provides quantitative bioactivity results, including a 60.4% inhibition rate for compound 5.
• Links chemical discovery to genomic evidence by identifying two functional enzymes, AtUbiA3 and Pan9.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific fungal strain and laboratory methods.

Provenance

Source

figshare

Collection Method

Chemical investigation and genome sequencing of a newly identified Aspergillus fungus.

Time Range

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Freshness

Last updated 2026-04-09 20:03:30; freshness should be verified.

Geography

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