Benzofuran-2-Carboxylic Acid Derivatives as PTPRO Inhibitors for IBD Treatment

A dataset of benzofuran-2-carboxylic acid derivatives identified as PTPRO inhibitors for inflammatory bowel disease research. It includes data on lead compounds 10j and 30k, detailing IC50 values, oral bioavailability, and in vivo efficacy from a murine colitis model. The dataset was authored by Xiao Liang and uploaded to figshare in April 2026.

Use Cases

• Train predictive models for PTPRO inhibitor potency based on compound structure and IC50 values.
• Analyze structure-activity relationships for benzofuran-2-carboxylic acid derivatives.
• Benchmark in vivo efficacy metrics for novel IBD drug candidates against murine model results.

Strengths

• Includes specific IC50 values for key compounds (0.54 μM for 10j, 0.16 μM for 30k).
• Describes in vivo efficacy results from a DSS-induced murine colitis model, including colon length and cytokine level data.
• Released under a CC-BY-NC-4.0 license, permitting non-commercial reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.3 KB, indicating limited scope.

Provenance

Source

figshare, authored by Xiao Liang.

Collection Method

Likely contains results from chemical library screening and structure-guided optimization.

Time Range

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Freshness

Last updated 2026-04-28 05:05:34; freshness should be verified.

Geography

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