Catechol-Benzothiazole Conjugates: Antibacterial Synergist Screening Data

A dataset from a study on synthesized catechol-conjugated benzothiazole derivatives designed to inhibit biofilm formation in Pseudomonas aeruginosa. The data likely contains results for a series of compounds, including the hit compound 4p with an IC50 of 0.27 μM for biofilm inhibition. The dataset was authored by Ying-Bo Zhou and last updated on 2026-05-04.

Use Cases

• Training models to predict biofilm inhibition based on chemical structure features mentioned in the description
• Analyzing structure-activity relationships for catechol-benzothiazole conjugates
• Studying synergy between novel compounds and antibiotics like ciprofloxacin and tobramycin
• Modeling the impact of iron-chelating compounds on bacterial virulence and motility

Strengths

• Includes data on a hit compound (4p) with a specific, potent biofilm inhibition IC50 value of 0.27 μM
• Describes in vivo validation results, including a 2.10–2.11 log10 CFU reduction in mice wound models

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small at 3.2 KB, indicating a limited scope of data points

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory synthesis and biological testing of chemical compounds.

Freshness

Last updated 2026-05-04 10:13:29; freshness should be verified