CN-3: Potency Data for a Next-Generation RET Inhibitor

Zi-Xuan Wang reports CN-3, a potent RET inhibitor active against clinically relevant mutants. The dataset likely contains potency measurements (IC50 values) for CN-3 against RET mutants and cellular models, as well as kinase selectivity profiling data. The data was last updated on 2026-05-02.

Use Cases

• Evaluate inhibitor potency against RET mutants based on IC50 values mentioned in the description
• Assess selectivity of a kinase inhibitor based on the kinase profiling results described
• Model dose-dependent antitumor efficacy in xenografts based on the reported efficacy data
• Analyze mechanisms of action such as signaling pathway blockade and apoptosis induction described

Strengths

• Potency data includes specific IC50 values (e.g., < 5 nM for mutants, 2.48 ± 0.78 nM for TT cells)
• Description details activity against multiple clinically relevant resistance mutations (G810R/S/C, V804M, Y806H, M918T)
• Includes results from multiple assay types: cellular proliferation, kinase autophosphorylation, and in vivo xenograft models

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (385.3 KB), indicating limited scope

Provenance

Source

Zi-Xuan Wang

Freshness

Last updated 2026-05-02 13:34:26; freshness should be verified