CN-3: Potency and Selectivity Data for a Next-Generation RET Inhibitor

A figshare dataset from 2026 by Zi-Xuan Wang details the experimental results for CN-3, a novel RET kinase inhibitor. The data includes IC50 values for CN-3 against multiple RET mutants and cell lines, such as TT and LC-2/ad cells, and results from kinase profiling and xenograft studies. The dataset is provided as a PDB file and is licensed under CC-BY-NC-4.0.

Use Cases

• Train predictive models for drug potency based on IC50 values against specific RET mutants.
• Analyze kinase inhibitor selectivity profiles using the provided off-target activity data.
• Benchmark new RET inhibitors against CN-3's performance in cellular proliferation assays.
• Study structure-activity relationships for RET inhibitors using the provided PDB file.

Strengths

• Includes specific IC50 measurements (e.g., 2.48 ± 0.78 nM for TT cells) for quantitative analysis.
• Covers multiple clinically relevant RET resistance mutations (G810R/S/C, V804M, Y806H, M918T).
• Provides data from multiple experimental models, including cellular assays and in vivo xenografts.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset's 386.0 KB size suggests a limited scope, likely containing summary results rather than raw high-throughput screening data.
• Data may reflect experimental bias inherent to the specific assays and models used in the source study.

Provenance

Source

Zi-Xuan Wang via figshare

Collection Method

Likely contains summarized results from biochemical, cellular, and in vivo pharmacological experiments.

Freshness

Last updated 2026-05-02 13:34:29; freshness should be verified.