INCB106385: Preclinical Data for a Dual A2A/A2B Adenosine Receptor Antagonist

Preclinical data for INCB106385, a dual A2A/A2B adenosine receptor antagonist developed for cancer immunotherapy. The dataset, shared by Chao Qi on figshare, includes information supporting the compound's advancement into Phase 1 clinical trials. It was last updated on 2026-05-27.

Use Cases

• Analyzing potency data for dual A2A/A2B receptor antagonism based on the described screening efforts.
• Evaluating drug-like properties and pharmacokinetic profiles across species mentioned in the description.
• Modeling efficacy in preclinical cancer models, such as the CT26 mouse colon carcinoma model referenced.

Strengths

• Data is associated with a compound that advanced to Phase 1 clinical trials (NCT04580485, NCT04989387).
• The description specifies favorable drug-like properties and limited CNS penetration for the compound.
• Dataset is shared under a CC-BY-NC-4.0 license, clarifying reuse terms.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 3.1 KB, indicating limited scope.

Provenance

Source

figshare, author Chao Qi.

Collection Method

Likely contains data from in-house screening efforts and preclinical studies as described.

Freshness

Last updated 2026-05-27 15:05:01; freshness should be verified.