Fosigotifator: eIF2B Activator Compound Data for ISR Modulation

Jennifer M. Frost published a dataset on figshare in May 2026 detailing the discovery of fosigotifator, a prodrug eIF2B activator. The 2.7 KB CSV file contains data related to improving the drug-like properties of ISR inhibitors, specifically solubility and absorption. This work is part of a research effort to develop clinical candidates for modulating the integrated stress response.

Use Cases

• Compare compound solubility and absorption properties based on the described structural modifications.
• Model structure-activity relationships for eIF2B activators based on the described analogue series.
• Analyze the progression of drug candidates from lead identification to prodrug development as described in the research narrative.

Strengths

• Data is associated with a specific, recently published research compound (fosigotifator) as of May 2026.
• File is small (2.7 KB) and in a standard CSV format, facilitating quick inspection.

Limitations

• Row count and specific column names are unknown, which obscures the dataset's structure and scale.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Jennifer M. Frost.

Collection Method

Likely contains experimental or computational data generated during a medicinal chemistry campaign.

Freshness

Last updated 2026-05-19 09:11:12; freshness should be verified.