Discovery of New Teraryl γ‑Lactam Derivatives as Potent Antibacterial Agents In Vitro and

Lishu Sheng published a dataset on figshare in April 2026 detailing the discovery of a novel antibacterial scaffold. It contains data on 42 synthesized derivatives, including structure-activity relationship analysis and in vitro/in vivo efficacy against drug-resistant bacteria like MRSA. The dataset includes mechanistic, proteomic, and pharmacokinetic data for the lead compound 8c.

Use Cases

• Training predictive models for antibacterial activity based on structural modifications of the teraryl γ-lactam scaffold.
• Analyzing structure-activity relationships (SAR) against multidrug-resistant Gram-positive bacteria like MRSA and VRE.
• Studying dual-action mechanisms of cell wall and membrane inhibition using associated proteomic and lipidomic data.
• Evaluating in vivo pharmacokinetic properties and liver microsomal stability for antibiotic candidates.

Strengths

• Contains data on 42 synthesized chemical derivatives, enabling comparative analysis.
• Includes in vivo pharmacokinetics and efficacy data for the lead compound 8c.
• Mechanistic data from proteomic and lipidomic analyses is described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to a single chemical scaffold and a defined set of bacterial strains.

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory synthesis, biological assays, and omics analyses described in the associated research.

Time Range

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Freshness

Last updated 2026-04-16 03:45:59; freshness should be verified.

Geography

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