Novel Coumarin Derivatives: Antiviral Activity Against Cucumber Mosaic Virus

54 novel coumarin derivatives were synthesized and evaluated for antiviral activity against cucumber mosaic virus (CMV). The dataset includes results from in vivo protective activity assays, mechanistic studies on defense enzymes and chlorophyll, and transcriptomic analysis. It was published by Lei Zhao on figshare in March 2026.

Use Cases

• Screen for lead compounds based on in vivo protective activity against CMV.
• Analyze structure-activity relationships for coumarin derivatives with benzyl chloride and dithioacetal moieties.
• Investigate plant defense mechanisms based on transcriptomic data and chlorophyll a/b-binding protein (CAB) expression.
• Assess pharmacokinetic and ecological risk profiles using in silico ADME analysis results.

Strengths

• Includes data for 54 specifically designed and synthesized novel compounds.
• Contains comparative efficacy data against the commercial agent ningnanmycin.
• Provides multi-faceted validation including in vivo activity, mechanistic enzyme studies, and transcriptomic analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is focused on a single virus (CMV) and a specific compound class, limiting generalizability.

Provenance

Source

figshare, author Lei Zhao.

Collection Method

Data from a study involving chemical synthesis, biological assays, and transcriptomic analysis.

Time Range

The study period is not specified.

Freshness

Last updated 2026-03-18 02:30:08; freshness should be verified.

Geography

Geographic coverage is not specified.