Discovery of Novel Therapeutic Target STMN1 and Drug Investigation in Familial Adenomatous

Shu Wang's dataset, shared on figshare in May 2026, contains data supporting the discovery of STMN1 as a therapeutic target for Familial Adenomatous Polyposis (FAP). The 3.0 MB dataset includes results from RNA sequencing of patient-derived organoids from seven FAP families and pharmacophore-based virtual screening from the DrugBank database. It details the development and testing of the novel small-molecule inhibitor JYL-6 in organoid and mouse models.

Use Cases

• Identifying gene expression biomarkers for FAP prognosis based on RNA sequencing data mentioned in the description
• Conducting drug repurposing and virtual screening studies based on the pharmacophore-based screening of DrugBank
• Evaluating compound efficacy in preclinical models based on organoid and Apcmin/+ mouse data
• Investigating STMN1 pathway inhibition as a therapeutic strategy for polyposis syndromes

Strengths

• Includes data from patient-derived organoids from seven distinct FAP families
• Contains results from pharmacophore-based virtual screening of the DrugBank database
• Provides preclinical validation data from Apcmin/+ mouse models

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

RNA sequencing of patient-derived organoids and pharmacophore-based virtual screening

Time Range

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Freshness

Last updated 2026-05-01 09:09:08

Geography

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