STAT3 PROTAC Degrader SD-965 Experimental Data

Experimental data details the discovery and evaluation of the STAT3 PROTAC degrader SD-965. The dataset contains results from design, synthesis, and in vivo testing in mouse models of human leukemia and lymphoma. It was authored by Dimin Wu and shared under a CC BY-NC 4.0 license.

Use Cases

• Analyze the efficacy of SD-965 in inducing STAT3 protein depletion in mouse native and human xenograft tumor tissues.
• Evaluate the selectivity of SD-965 by examining data on the non-depletion of other STAT proteins.
• Assess the therapeutic potential of SD-965 using results from tumor regression studies in human leukemia and lymphoma xenograft models.
• Study the design and synthesis parameters linking high-affinity STAT3 ligands and cereblon ligands to degrader potency.

Strengths

• Data originates from a published scientific study on a promising therapeutic target for human cancers.
• Includes specific results from in vivo testing in mouse models, including tumor regression data.
• Shared under a clear CC BY-NC 4.0 license for defined reuse.

Limitations

• The dataset is very small at 6.3 KB, indicating limited scope and likely summary-level results rather than raw experimental data.
• Specific data structure (rows, columns, sample data) is not provided, limiting immediate analytical utility.
• The temporal coverage and update frequency of the underlying experimental data are not specified.

Provenance

Source

figshare, authored by Dimin Wu.

Collection Method

Data generated from the design, synthesis, and biological evaluation of novel STAT3 PROTAC degraders in a research study.

Freshness

Last updated in March 2026, indicating recent availability on the platform.