Small-Molecule Inhibitors of the Pycsar Antiphage Defense System

A dataset reporting the first small-molecule inhibitors of the Pycsar bacterial immune system, a 3′,5′-cCMP signal-based defense mechanism. The data was authored by Marian A. Addo and published on figshare under a CC-BY-NC-4.0 license on April 23, 2026. The inhibitors were shown to enable a phage to overcome Pycsar-mediated resistance in Escherichia coli cells.

Use Cases

• Screening for chemical modulators of bacterial immunity based on the described Pycsar system.
• Enhancing phage therapy efficacy against resistant pathogens based on the described inhibitor mechanism.
• Studying the specific targeting of transmembrane effector proteins in bacterial defense systems.
• Investigating the role of 3′,5′-cCMP signaling in bacterial antiviral responses.

Strengths

• Dataset is focused on a novel, first-reported discovery of small-molecule inhibitors for a specific bacterial defense system.
• The description provides a clear biological mechanism, involving the Pycsar system's two proteins and the cCMP signal.
• Data is published under a CC-BY-NC-4.0 license, permitting non-commercial reuse with attribution.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is very small at 9.8 KB, suggesting limited scope or preliminary data.
• The description metadata is limited; actual data structure and content require manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from a research study, as described.

Time Range

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Freshness

Last updated 2026-04-23 14:04:30; freshness should be verified.

Geography

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