Povorcitinib (INCB054707): JAK1 Inhibitor Discovery Data

386.2 KB of structural data for the JAK1-selective inhibitor povorcitinib (INCB054707), authored by Jincong Zhuo and last updated in May 2026. The dataset, shared on figshare under a CC-BY-NC-4.0 license, includes protein crystallography information supporting the compound's selectivity and improved pharmacokinetics. It was used to demonstrate dose-dependent efficacy in murine arthritis models.

Use Cases

• Analyzing JAK1 vs. JAK2 selectivity based on protein crystallography data mentioned in the description
• Studying structure-activity relationships for hinge-binding motifs in kinase inhibitors based on the described molecular scaffold
• Modeling pharmacokinetic properties influenced by intramolecular hydrogen bonding as described for the amide moiety
• Validating computational docking predictions using the described small lipophilic groove in the JAK1 P-loop conformation

Strengths

• Includes protein crystallography data that explains the molecular basis for JAK1 selectivity.
• Describes iterative breakthroughs leading to a compound with improved pharmacokinetics.
• Data is associated with efficacy results from murine arthritis models mentioned in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 386.2 KB size indicates a very limited scope of data.

Provenance

Source

Jincong Zhuo via figshare.

Collection Method

Likely generated through medicinal chemistry research, protein crystallography, and in vivo efficacy studies.

Freshness

Last updated 2026-05-27 20:10:57; freshness should be verified.