Discovery, Synthesis of Myrtucommulone B Analogs as Soluble Epoxide Hydrolase Inhibitors a

A figshare dataset by Jia-Rui Sun, last updated in April 2026, details the synthesis and evaluation of novel myrtucommulone B derivatives as soluble epoxide hydrolase (sEH) inhibitors. The dataset, 11.3 KB in size, likely contains results from bioassays measuring sEH inhibition, toxicity, and anti-inflammatory effects in vitro and in vivo. This work provides a foundation for developing new anti-inflammatory and analgesic agents, with a focus on potential therapeutics for acute pancreatitis.

Use Cases

• Training predictive models for sEH inhibitor activity based on compound structure and bioassay results.
• Analyzing structure-activity relationships (SAR) for myrtucommulone B derivatives.
• Screening for lead compounds with low toxicity and robust in vivo anti-inflammatory effects.
• Investigating the correlation between sEH inhibition and changes in inflammatory biomarkers like EETs and DHETs.

Strengths

• Dataset is licensed under CC-BY-NC-4.0, allowing for non-commercial reuse with attribution.
• The description provides specific biological results, including the identification of a potent derivative ((+)-34) with low toxicity.
• The dataset is small (11.3 KB), facilitating quick download and initial inspection.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains synthesized experimental data from laboratory bioassays.

Freshness

Last updated 2026-04-21 19:34:58; freshness should be verified.