Ferroptotic and Necrotic Cell-Death Mechanisms from Phenotypic Screening

A dataset investigates the ferroptotic and necrotic activities of the lethal small molecule CIL56 and related analogs. It includes results from a phenotypic suppressor screen identifying distinct sets of small molecules that selectively attenuate different death modalities. The data is provided in an XLSX file of 81.0 KB.

Use Cases

• Analyze the distinct ferroptotic and necrotic activities of CIL56 and related analogs to separate death phenotypes.
• Classify suppressor compounds based on shared ligand-based target predictions to identify candidate protein targets linked to each death modality.
• Integrate phenotypic screening data with suppressor classification to prioritize candidate proteins and pathways underlying the observed biological response.
• Investigate the heterogeneous cell-death programs induced by small molecules to improve mechanistic interpretation of phenotypic screens.

Strengths

• Data is derived from a documented phenotypic suppressor screen investigating specific cell-death mechanisms.
• The dataset is structured for analysis of distinct death phenotypes (ferroptotic vs. necrotic) from structurally similar compounds.
• The 81.0 KB XLSX file indicates a focused dataset suitable for targeted mechanistic analysis.

Limitations

• The dataset is small in scale (81.0 KB), limiting the scope for broad statistical or machine learning applications.
• Specific data structure details like row count, column names, and sample data are unavailable, complicating direct usability assessment.
• The dataset is focused on a specific set of compounds and cell-death mechanisms, which may limit generalizability to other biological contexts.

Provenance

Source

figshare, authored by Kenichi Shimada.

Collection Method

Generated from a phenotypic suppressor screen and subsequent analysis of small-molecule activities and target predictions.

Freshness

Last updated on 2026-03-24.