Rat Tibia pQCT Data on Dose-Dependent Bone Loss from Reduced Loading

NASA research data from a study exposing 14-week-old male Wistar rats to varied levels of partial weight bearing (20%, 40%, 70%, 100%) for 1, 2, or 4 weeks. The dataset contains results from in vivo pQCT (peripheral Quantitative Computed Tomography) assays on tibia tissue, measuring trabecular bone density and structural alterations. The study was last updated on 2026-03-13.

Use Cases

• Modeling dose-response relationships between mechanical loading and bone density based on the described weight-bearing percentages.
• Analyzing time-progressive bone deterioration based on the 1, 2, and 4-week experimental durations.
• Comparing trabecular versus cortical bone responses to unloading as suggested by the study's findings.

Strengths

• Experimental design includes multiple controlled variables: four weight-bearing levels (20%, 40%, 70%, 100%) and three time points (1, 2, 4 weeks).
• Sample size is specified as 11-12 rats per experimental group.
• Data originates from a controlled animal study conducted by NASA, suggesting methodological rigor.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to a single rat strain (Wistar) and sex (male), limiting generalizability.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Controlled laboratory experiment using in vivo pQCT and ex vivo microcomputed tomography on rat tissue.

Time Range

Experimental durations of 1, 2, and 4 weeks.

Freshness

Last updated 2026-03-13 19:55:53.410619; freshness should be verified.

Geography

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