DoseFinding: Statistical Functions for Pharmaceutical Dose-Response Experiments

The DoseFinding package provides functions for designing and analyzing dose-finding experiments, with a focus on Phase II clinical trials. It includes methods for multiple contrast tests, fitting non-linear dose-response models, calculating optimal designs, and implementing the MCPMod methodology. The package was authored by Bjoern Bornkamp.

Use Cases

• Designing Phase II clinical trials based on the described dose-response methodology.
• Analyzing dose-response relationships using the package's non-linear model fitting functions.
• Implementing the MCPMod methodology for model-based dose finding as referenced in the description.
• Calculating optimal experimental designs for dose-finding studies.

Strengths

• Provides a specific implementation of the MCPMod methodology, a recognized statistical approach.
• Includes both Bayesian and non-Bayesian estimation methods for model fitting.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Bjoern Bornkamp

Collection Method

Software package for statistical analysis.