Christiane de Fátima Colet conducted an open cohort prospective study over 18 months with warfarin users attending public health clinics in Ijuí, Brazil. The study followed 68 patients, with 63 completing it and 5 dying, and collected data via monthly home interviews and medical record review. It reports a mean of 9.6 medications per patient, 2.91 interactions involving warfarin, and 87 bleeding episodes.
Use Cases
- Predicting bleeding risk based on reported drug interactions and concomitant medications like omeprazole and simvastatin.
- Analyzing the relationship between vitamin K intake and adverse events in anticoagulated patients.
- Identifying patterns of polypharmacy and its correlation with adverse event frequency.
- Building models to classify drug interaction severity (severe vs. moderate) based on patient profiles.
Strengths
- Data collection involved monthly home interviews and medical record confirmation, suggesting a multi-source validation approach.
- The study reports specific quantitative findings: 68 patients, 9.6 mean medications, 2.91 mean warfarin interactions, 87 bleeding episodes.
- Potential drug interactions were evaluated in a database and vitamin K consumption was quantified using a validated method.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- Data may reflect geographic bias inherent to a single-city study in Brazil.
Provenance
- Source
- Christiane de Fátima Colet
- Collection Method
- Open cohort prospective study with data collected via monthly home interviews and medical record review.
- Time Range
- 18-month study period
- Geography
- Public health clinics in Ijuí, Brazil