Experimental Data for Hyaluronic Acid Nanoemulsion Gel in Osteoarthritis Treatment

Figshare hosts a 2.2 MB research dataset by Noor Assalem, published in April 2026, detailing a novel intra-articular drug delivery system for osteoarthritis. The dataset contains experimental results, including nanoparticle droplet size (214.5 ± 19.54 nm) and polydispersity index (0.387 ± 0.060), for a syringic acid nanoemulsion within a hyaluronic acid/poloxamer in-situ gel. In-vivo efficacy data from a knee osteoarthritis induction model in rats is included, comparing inflammation and cytokine levels against a control suspension.

Use Cases

• Analyze the relationship between nanoemulsion droplet size and polydispersity index data to predict formulation stability.
• Model the sustained release profile of syringic acid, which approaches 6 days, from the in-situ gel matrix.
• Correlate in-vivo experimental metrics like pro-inflammatory cytokine levels and joint inflammation scores with different treatment formulations.
• Study the sol-gel transition temperature and rheological patterns documented for the HA/P407/P188 polymer blend.

Strengths

• Dataset provides specific, quantified experimental results, including droplet size (214.5 nm) and polydispersity index (0.387).
• Includes comparative in-vivo efficacy data from an osteoarthritis animal model.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Dataset is very small at 2.2 MB, likely containing only summary figures, documents, and key results rather than raw, granular data.
• No raw data tables or column descriptions are provided, limiting computational analysis.
• Temporal and geographic scope of the underlying study is not specified.

Provenance

Source

Noor Assalem via figshare.

Collection Method

Experimental laboratory research involving nanoparticle formulation, characterization, and in-vivo animal testing.

Time Range

null

Freshness

Last updated in April 2026, indicating recent research.

Geography

null