Dual-Mechanism Vitamin C Delivery by GDS-23 Niosomes via SVCT2 Induction

A dataset from Tatsuro Miyoshi, last updated in May 2026, presents research on a polyethylene glycol-23 glyceryl distearate (GDS-23) nanocarrier system. It includes data on mRNA expression levels of antioxidant transporters xCT and SVCT2 in human keratinocytes and skin permeation results from a three-dimensional epidermis model. The 99.6 MB dataset contains TIF and DOCX files.

Use Cases

• Evaluate nanocarrier efficacy for transdermal drug delivery based on skin permeation data.
• Study the relationship between Nrf2 pathway activation and transporter induction based on mRNA expression data.
• Compare protective effects of different antioxidant molecules (e.g., L-ascorbic acid vs. cysteine) encapsulated in niosomes against oxidative damage.

Strengths

• Dataset includes specific molecular biology results, such as mRNA expression data for SLC7A11/xCT and SVCT2.
• Research employs a three-dimensional reconstructed epidermis model for skin permeation evaluation.
• Files are provided in common research formats (TIF, DOCX) totaling 99.6 MB.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental bias inherent to the single-laboratory study on figshare.

Provenance

Source

figshare

Collection Method

Experimental research involving cell culture, gene expression analysis, and skin model assays.

Freshness

Last updated 2026-05-30 18:14:32; freshness should be verified.