14c: Dual Metabolic Inhibition and Immunogenic Cell Death in Pancreatic Cancer

Compound 14c is a mitochondria-targeted small molecule designed to disrupt pancreatic ductal adenocarcinoma energy metabolism. The dataset likely contains results from in vitro and in vivo experiments demonstrating inhibition of glycolysis and oxidative phosphorylation, induction of ferroptosis, and elicitation of immunogenic cell death hallmarks. The data was uploaded by Haibo Yan on figshare in May 2026.

Use Cases

• Analyze the efficacy of dual metabolic blockade based on PDAC cell glycolysis and mitochondrial function inhibition results
• Investigate ferroptotic cell death mechanisms based on lipid peroxidation and redox imbalance data
• Evaluate immunogenic cell death induction based on calreticulin exposure and HMGB1 release measurements
• Assess therapeutic potential and systemic toxicity based on tumor growth suppression in a syngeneic PANC02 model

Strengths

• The dataset is associated with a specific, rationally designed compound (14c) described in a research study.
• The description details multiple experimental contexts, including in vitro and in vivo (syngeneic PANC02 model) results.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (1.3 KB), indicating limited scope.

Provenance

Source

figshare

Freshness

Last updated 2026-05-21 20:44:15; freshness should be verified.