Endometrial Gene Expression in Women with Ovarian Endometrioma, 42 Participants

A cross-sectional study of 42 women (32 infertile, 10 fertile controls) investigated endometrial gene expression in relation to ovarian endometrioma. The dataset includes measurements of podocalyxin (PCX) and leukemia inhibitory factor (LIF) mRNA and protein levels from tissue samples obtained via laparoscopy or hysteroscopy. The data was published by Gökçenur Karakelleoğlu on figshare in April 2026.

Use Cases

• Analyzing the correlation between progesterone levels and PCX expression based on the negative correlation reported in the description.
• Comparing LIF mRNA expression levels between women with ovarian endometrioma and other groups based on the significant differences found.
• Investigating the relationship between PCX and LIF expression based on the strong negative correlations described.
• Studying potential biomarkers for impaired endometrial progesterone responsiveness based on the PCX–LIF transition disruption.

Strengths

• Includes data from 42 participants with defined subgroups (17 with ovarian endometrioma, 7 with non-endometriotic cysts, 8 with prior infertility treatment failure, 10 fertile controls).
• Provides specific statistical results, including p-values (< 0.001) and correlation coefficients (e.g., r = -0.81).
• Analyzes both mRNA and protein levels for key biomarkers (PCX and LIF).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (295.8 KB), indicating a limited scope.

Provenance

Source

figshare

Collection Method

Endometrial tissue samples analyzed via qRT-PCR and ELISA.

Time Range

Study period not specified in input.

Freshness

Last updated 2026-04-22 05:31:12; freshness should be verified.

Geography

Geographic scope of participants not specified in input.