Apoptosis Gene Expression in Breast Cancer Subtypes and Cryoablation Response

Gene expression data from mRNA microarrays and miRNA profiling analyzes apoptosis-related signaling across five molecular subtypes of breast cancer and systemic responses to benign fibroadenoma cryoablation. The dataset includes scores for intrinsic and extrinsic apoptotic pathways and an apoptotic balance index (ABI). It was created by Agata Panfil and last updated on June 2, 2026.

Use Cases

• Compare apoptotic pathway activity across breast cancer molecular subtypes based on the HALLMARK_APOPTOSIS gene set scores.
• Investigate miRNA-mRNA interactions related to apoptosis using the identified miRNAs (e.g., miR-582-5p, miR-421).
• Analyze differences in apoptotic gene expression (e.g., BIK, BMF, HSPB1) between malignant tissue and regulated injury responses.
• Validate potential biomarkers for tumor aggressiveness, such as the apoptotic balance index (ABI), in triple-negative and HER2-positive cancers.

Strengths

• Integrative analysis combines mRNA microarray, qRT-PCR, and ELISA validation data.
• Includes analysis across five distinct molecular subtypes of breast cancer.
• Provides a specific apoptotic balance index (ABI) for pathway-level interpretation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 137.5 KB, indicating a limited scope of data.

Provenance

Source

figshare

Collection Method

Gene expression profiling via mRNA microarrays, validated by qRT-PCR and ELISA, with miRNA profiling and in silico analyses.

Freshness

Last updated 2026-06-02 09:41:24; freshness should be verified.