Early Striatal Hyperexcitability in a Human iPSC Parkinson's Disease Microcircuit Model

Tabular datasets from a study modeling Parkinson's disease using induced pluripotent stem cell-derived neurons in a custom microfluidic platform. The data includes source data plotted on main and supplementary figures, a key resources table, and a list of primers. The research was conducted by Quyen Do at the University of Oxford.

Use Cases

• Analyze medium spiny neuron synaptic activity based on electrophysiological measurements mentioned in the description
• Model the effects of the GBA-N370S mutation on neuronal excitability based on voltage-gated ion current data
• Investigate dopaminergic transmission's role in neuronal maturation based on circuit activity data
• Validate in vitro microcircuit models of the basal ganglia based on the modular platform data

Strengths

• Data is directly linked to published scientific figures, providing traceability
• Includes multiple structured Excel files covering source data, supplementary data, and key resources

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Last update date is unknown; freshness unverified

Provenance

Source

University of Oxford

Collection Method

Generated from experiments using a custom three-chamber microfluidic platform with iPSC-derived neurons.