773 KB of experimental data from a study exploring the pathogenic role of the JAK1-pSTAT1 axis in proteinopathy. The dataset likely contains measurements from mouse and cell models of increased proteotoxic stress, including cardiomyocyte-restricted Jak1 ablation (Jak1-cko) and CryABR120G overexpression. It was authored by Xuejun Wang and last updated on May 18, 2026.
Use Cases
- Analyzing the impact of Jak1 ablation on cardiac function based on the described cardiomyopathy model.
- Investigating the attenuation of proteostasis impairment via JAK1 inhibition based on the itacitinib administration experiments.
- Studying diastolic malfunction in mouse hearts overexpressing misfolded protein CryABR120G.
- Evaluating the decoyed activation of the JAK1-STAT pathway under proteotoxic stress conditions.
Strengths
- Data is associated with a published study providing compelling in vivo support for a pathogenic pathway.
- Files are available in DOCX and XLSX formats, suggesting structured documentation and tabular data.
- License is CC-BY-4.0, allowing for open reuse and redistribution.
Limitations
- Row count and column definitions are unknown, limiting suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is small (773 KB), indicating limited scope.
Provenance
- Source
- figshare
- Collection Method
- Likely generated from laboratory experiments on mouse and cell models.
- Freshness
- Last updated 2026-05-18 22:17:14; freshness should be verified.