Meta-Analysis of Intensive vs Standard Blood Pressure Control on Cardiovascular Outcomes

156,933 participants from 31 randomized controlled trials were analyzed in this meta-analysis. The study, authored by Qiu Gao and updated in April 2026, systematically evaluates the impact of intensive versus standard blood pressure control on major cardiovascular events, myocardial infarction, stroke, and mortality. Pooled relative risks were calculated using a random-effects model based on trials published up to May 2025.

Use Cases

• Validate the efficacy of lower blood pressure targets based on pooled relative risk data
• Assess heterogeneity of treatment effects based on sample size and patient characteristics mentioned in the description
• Support clinical guideline development based on meta-analytic findings for major cardiovascular events

Strengths

• Analysis includes 31 randomized controlled trials with a total of 156,933 participants
• Results are supported by sensitivity analyses confirming robustness
• Study provides specific relative risk estimates with 95% confidence intervals for five key outcomes

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is a 1.9 MB DOCX file, which may limit programmatic analysis compared to structured formats

Provenance

Source

Qiu Gao

Collection Method

Systematic searches of PubMed, Embase, Web of Science, and the Cochrane Library for relevant RCTs.

Time Range

Trials published up to May 2025; participant follow-up duration ranged from 1.8 to 19.3 years.

Freshness

Last updated 2026-04-30 07:50:39; freshness should be verified

Geography

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